![]() This article surveys the design, mode of action, and capabilities of state-of-the-art mRNA vaccines, focusing on the paradigm of influenza prophylaxis. Messenger RNA vaccines induce balanced immune responses including B cells, helper T cells, and cytotoxic T lymphocytes, rendering them an extremely adaptable platform. The formation of native antigen in situ affords great versatility, including intracellular localization, membrane association, posttranslational modification, supra-molecular assembly, or targeted structural optimization of delivered antigen. ![]() (3) RNA can be tailored to provide potent adjuvant stimuli to the innate immune system by direct activation of RNA-specific receptors this may reduce the need for additional adjuvants. This greatly reduces general complications associated with biological vaccine production, such as handling of infectious agents, genetic variability, environmental risks, or restrictions to vaccine distribution. The Moderna COVID-19 vaccine is a messenger RNA (mRNA) based vaccine against coronavirus disease 2019 (COVID-19). (2) mRNA vaccines are synthetically produced by an enzymatic process, just requiring information about the nucleic acid sequence of the desired antigen. These characteristics also guarantee tight control over their immunogenic profile (including avoidance of vector-specific immune responses that could interfere with repeated administration), pharmacokinetics, and dosing. In the environment and upon physical contact, RNA is rapidly degraded by ubiquitous RNases and cannot persist. At the conceptual level, mRNA-based vaccines-more than other genetic vectors-combine the simplicity, safety, and focused immunogenicity of subunit vaccines with favorable immunological properties of live viral vaccines: (1) mRNA vaccines are molecularly defined and carry no excess information. These data indicate wider applicability to infectious disease and should encourage continued translation of mRNA-based prophylactic vaccines into human clinical trials. ![]() Twenty years after the demonstration that messenger RNA (mRNA) was expressed and immunogenic upon direct injection in mice, the first successful proof-of-concept of specific protection against viral infection in small and large animals was reported.
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“ Spike user interface is much more intuitive and I love how everything is organized by conversation rather than by individual messages like Hangouts.Business – For power users & large teams.Spike is the first native desktop and mobile app that combines all forms of team communication in your Inbox, which works seamlessly both internal communication and externally to your organization. All Spike needs is for you to sign in with your email account. ![]() With Spike, you have everything you need to create the best Google Hangouts and Google Meet alternative without needing to deploy yet another service. Just because your team is distributed or remote, doesn’t mean you can’t still build relationships. Spike promotes a collaborative environment where it’s as easy to email as it is to send a text message. There can be no ‘water cooler’ talk when there is no water cooler. Likewise, there are different video conferencing services available, but they’ll be another account to manage (and purchase) on top of your email and team-chat app.įor teams that are working remotely, there is often a loss of chats and conversations that help build rapport and deepen work relationships. There are other great team communication apps, but their limitations are exposed when you need to chat with clients. When there are multiple people on the call, emoji reactions let everyone give a quick thumbs up when an agreement is needed. Spike Video Meetings also support screen sharing, making it perfect for sharing a presentation about your last mock-up or website draft. Every meeting can be joined with one click. Invites can be sent without starting a new thread or email, so you can go from text to voice message to a video call in the same email thread, all without launching another app.Įven if the person you’re meeting with doesn’t use Spike, they can join using any web browser on any device without needing to register for an account, install a plugin, or adjust any complicated settings. Spike lets you schedule Video Meeting invites in your calendar events or over email. In addition, Spike Video Meetings are integrated into Spike’s app, so you don’t need to use Zoom or Google Hangouts. Spike’s Video Meetings and video chat services are one of the easiest to use services available in any app. Its streamlined interface makes it the best Google Hangouts alternative. Spike delivers everything you could ever need from a digital workspace in a single app across every platform, from email, team chat, collaborative Notes to Video Meetings. ![]() All conversations related to that topic can take place in the Room, and only the necessary people can be included. For instance, you could create a Room specifically for a discussion about a particular project or event. Rooms are helpful for creating more focused chat spaces. Instead of having all conversations take place in a single stream like a regular group chat, Google Chat allows you to organize your conversations into “Rooms.” Organizations and groups can create their own Google Chat servers for their employees or members. It’s available on desktop, iPhone, iPad, and Android devices. ![]() But what does this actually mean? Essentially, Google Chat is a messaging app designed for teams. Google Chat is more of a competitor to a team chat app than a replacement for Google Hangouts. Just as with Google Inbox, Google often has big ideas with little stability in the long term. It’s difficult for teams to consistently change their apps and services every time Google sunsets a product and replaces it with a new one. Over the years, Google’s team communication has changed on an almost quarterly basis. Google replaced the original Hangouts with Chat and deprecated it on November 1, 2022. Initially, the service was only available to Google Workspace customers, but in February 2021, Google started offering Google Chat to regular consumer accounts in “early access” until it was fully available in April 2021. On April 9, 2020, it was renamed to Google Chat. The service was launched on March 9, 2017, as part of the two-app replacement for Google Hangouts, with the other app being Google Meet. Users can access the service through its website and app or through the Gmail website and app. The service provides direct messaging, group conversations, and spaces, which allow users to create and share tasks and files. Initially designed for business environments and teams, it’s now available for general consumers. ![]() Google Chat is a communication service offered by Google, previously known as Hangouts Chat. ![]() Each tile needs to be applied as close together as possible so that no water / grime gets underneath!.A pair of scissors, ruler & a squeegee will be your best friend during application!.Make sure your area is flat, free of any dirt & grime before applying (if you apply on top of grime the adhesive may not bond with your surface, uneven surfaces may cause the tiles not to stay adhered). ![]()
![]() ![]() Oh, and his shoes are something else leopard print! Tom's business card is the best since Patrick Bateman, the magnetism might put him over the top. Loved the use of the sound effect on Anne's phone. Anne constantly getting emails and Chris' line, "Your inbox is, literally, filled with penises," took full advantage of the premise. Was almost caught off guard by how fast Wiener scandal got used, but they used it to great effect. Entertainment 7twenty seems to not do a whole lot in its infancy, but I think the possible Andy/Tom dynamic could be great if Andy ends up working for the upstart. ![]() I will miss Andy and his antics/interactions at the shoe shine station who is going to not buy Mouse Rat CD’s now. Andy replacing Tom is an interesting choice, don't see him lasting long to be honest, but it will be nice to see Andy do something different (yes I know he has been an assistant for the Parks Department before). That's about it for plot though the rest is all set up. I am curious, who is Leslie’s antagonist going to be and will Tom’s company represent them in some capacity? Surely we will see some romantic entanglements along the way though right? It could be interesting to throw a scandal into the race. Adam Scott just nails it and it ends the relationship on as upbeat a note as possible to assure their eventual rekindling. This forces Leslie's hand with Ben, three months prematurely, and we are treated to possibly the sweetest breakup scene I have ever seen. Leslie’s campaign team sees an opportunity to position herself as a woman, who can't possibly send a picture of her penis to anyone. Leslie's campaign is thrust forward after our favorite sewage employee sends a picture of his penis to all the women at city hall. The plot was simple and straight forward, setting the board for the season, but all the character beats killed from start to finish. ![]() In fact, once you have an invoicing system that works for your business, you can start creating invoices in a matter of minutes.įortunately, Microsoft Word has made it easy to make professional and functional invoices for free. Now, we aren’t magicians, but there are better solutions to invoicing then typing away at a computer all day. Imagine if you could wave a magic wand and see all the tedious hours of creating and managing invoices melt away. Microsoft Word Invoicing for Small Businesses Check out our template gallery here to find and download invoice templates that suit you best. No matter what industry you’re in, from artists to electricians, we’ve got an invoice template to meet your needs. Simply download, edit, send and get paid. Invoice generators do all the legwork for you, so that you can focus on running your business. With the free Microsoft Word invoice template from FreshBooks, you don’t have to struggle to create functional invoices for your clients.īlank invoice templates are the ideal way to get paid without dealing with the hassle. Stuck on how to make invoices that are functional yet easy to use? No worries. That’s why the accounting software you use is important-and why creating professional invoices can make the difference in you getting paid on time. Get Your Free Microsoft Word Invoice TemplateĪs a small business owner, you’re the expert in your field and your clients count on you to give high-quality service, every time. Send invoices, track time, manage payments, and more…from anywhere. Pay your employees and keep accurate books with Payroll software integrationsįreshBooks integrates with over 100 partners to help you simplify your workflows Set clear expectations with clients and organize your plans for each projectĬlient management made easy, with client info all in one place Organized and professional, helping you stand out and win new clients ![]() Track project status and collaborate with clients and team members Time-saving all-in-one bookkeeping that your business can count on Tax time and business health reports keep you informed and tax-time readyĪutomatically track your mileage and never miss a mileage deduction again Reports and tools to track money in and out, so you know where you standĮasily log expenses and receipts to ensure your books are always tax-time ready Quick and easy online, recurring, and invoice-free payment optionsĪutomated, to accurately track time and easily log billable hours Recurring business invoices contain the same products and prices – it's sent to the same client every month or in the repeating period of time – for example, every 2 weeks.Wow clients with professional invoices that take seconds to create Among specific information, you can find the reason for crossing the border, country of origin, the Harmonized System Codes, and more. However, they are used for a specific purpose – transporting goods internationally and clearing customs. With proforma invoices, payment is not required, it's just some kind of an invoice draft that serves as a starting point for negotiation with a customer or an approval of business terms.Ĭommercial invoices are quite similar to a standard business invoice. This invoice type is similar to an estimation or a quote. Standard invoices contain the basic information needed to record and pay an invoice such as seller and customer details, goods or services delivered, invoice number, the date when the invoice is issued. There only several invoice types that most businesses would use to send to their customers: ![]() Bridgemarq is a leading provider of services to real estate brokers and agents. (formally Brookfield Real Estate Services Inc.). When you join Royal LePage Commercial Westhaven brokerage, you have the backing of one of the most powerful commercial real estate services company in Canada-Bridgemarq Real Estate Services Inc. Innovation and service excellence have developed and propelled the Royal LePage brand since 1913. In addition, agents will be able to access Royal LePage’s national referral network of over 18,000 agents to develop more business in their target markets with incoming leads generated daily. The brokerage provides agents a suite of services including marketing, promotional, networking and professional development needs. Agents can expect unlimited market boundaries to build their business without the interference of a heavy corporate structure. We offer commercial real estate agents a professional environment, focused 100% on commercial real estate. Our national partnerships help us establish, guide and execute successful business investments. We help businesses identify opportunities and maximize their return on investment with actionable goals, centralized support services and a strong commitment to customer success. ![]() Our commercial real estate industry and segment expertise coupled with Royal LePage’s national platform and integrated systems provides best-in-class real estate strategies and a competitive advantage that can’t be beat. What does it mean to "add value" to a commercial real estate investment? First National Realty Partners. NET operating income: What you need to know. In that case, it is important to consult with a professional to determine whether a property is a right fit for you and your business. Suppose you are looking to invest in commercial real estate. This can include adding amenities to the property to justify lease rates, renovating the property's exterior to improve appearance, and leasing units at fair and current market rates.ĭetermining your NOI before investing in a property will reveal whether owning and maintaining the property is worth the overall expense. There are many ways one can add value to a property while maintaining operating expenses. The higher the revenue and fewer operating expenses, the more profitable the property is. ![]() Operating expenses can include property management fees, insurance, utilities, property taxes, and maintenance and repair costs. ![]() Properties can generate revenue in many ways, including through rental income, paid parking, or laundry facilities. To calculate NOI, one must subtract all operating expenses incurred on the property from the revenue generated. This, in turn, makes it easier to compare different properties that potentially hold more value. NOI helps potential investors determine how much income they can expect from the property, otherwise known as the capitalization rate. So, what is net operating income? Net operating income (NOI) is a calculation that is used to analyze the profitability of income-producing real estate investments before adding in any costs from financing or taxes. Determining the net operating income (NOI) of the property before signing on the dotted line will better understand if the property adds value to your portfolio. Investing in commercial real estate can lead to increased profitability if done correctly. How to add value to your commercial real estate investment. ![]() The viewport is only dependent on the screen size and mostly identical for both cases, so let's ignore that for now.īut how is the rest of the map stored? It always needs to be completely in memory for the map to work, and that uses RAM.Ī single tile of a tiled map uses one number for each layer ("Place tile number # here"). In both cases (parallax and tiled) you have a viewport of what you can see and the map storage itself. However, from experience I can say that is a very tedious thing to get some mathematics on the difference. But they increase map transition lag, because they use a ton of CPU resources, especially in larger numbers (of hundreds).Įssentially the best way to optimize the MV engine would be to make the loading asynchronous with a smart preloader. Then they notice the pointers are empty, so they will load new assets without releasing the previous pointers, essentially resulting in memory leak that will ultimately lead to a crash).ĭoodads are a nice solution. They will preload the assets you will ask them to (However, they are constructed in such a way that when the garbage collector flushes the images, the empty pointers will remain. TDDP preload manager and SRD's preloader core sacrifice RAM for CPU too. Nevertheless, too much can lead to crashes. ![]() Parallax mapping sacrifices RAM for CPU power, because you don't have to render and handle X objects. MV loads resources on demand, so it sacrifices CPU for RAM, but ultimately results in lag. You have to remember that you cannot optimize the game for every situation. ![]() We both were in grand spirits, that is until breakfast was served. It was a great time for quiet recollection of our first week, and minor adjustments to our plans for the second. Obviously, when a place is jammed beyond capacity by an appreciative crowd, all ordering at once as fast as a server could get to them, there is going to be a wait. We were promptly served with transfusions of fragrant piping coffee, and left to study the menu. It is just as well that the pastor’s homily was short and sweet, because another ten minutes would have left us at the end of a lengthening line, apparently all fellow church-goers. The café, as neat as a pin, and smelling like the king’s own bakery, was just opening and we were seated among the first patrons that morning. Here we were in short sleeves and light slacks enjoying a delicious breakfast of sage laced biscuits with a superb sausage gravy out of doors on a 77 degree Sunday morning. Mrs Too and I were finally getting over the memory just one week ago, of being all bundled up against the 22 degree morning and backing her car out of the snow covered driveway. However, there is plenty of seating available outside for those waiting. Note that this restaurant is distinctly dog-friendly for outside eating, not only providing water dishes for accompanying pets but often also offering pet treats to waiting pooches (with owner permission.) One caution: Especially on week-ends during peak season, waiting time can be up to 20 – 30 minutes. Outside seating accomodates an additional 30 – 40. There is seating for a guesstimated 70 patrons, a mixture of booths, tables and counter stool seating. This not a place to go for fancy ambience. The cafe inside is clean but downright basic. ![]() It can be easy to miss, but look for the prominent Anna Maria Oyster House which is located in the same square. Sage Biscuit Cafe is located in a small strip mall/square named Cortez Village Square. One gets the sense that the servers genuinely want to know how the customer is enjoying the experience. Service is always cheerful, friendly and attentive. a Sake Bloody Mary which turned out to be both interesting and enjoyable. Beer and wine selection is quite limited, but drink selection for lunch/brunch includes a couple of creative touches including “wine based vodka” Bloody Mary and Sunset Cocktail. ![]() We have tried a couple of those and greatly enjoyed them. The menu includes a goodly number of vegetarian offerings for those so inclined. So far we have not had a single culinary disappointment. and also to date a somewhat smaller selection of the very wide variety of lunch offerings. But whenever we are anywhere near the neighborhood (or make an excuse to detour nearby) during breakfast or lunch time, then we drop by and are trying to work our way through as much of the menu as is feasible, including Huevos Rancheros, multiple Eggs Benedictine and breakfast skillet variations, stuffed French toast creations, omelets, etc. To our regret we do not live near Sage Biscuit. The complete menu can be perused by clicking on TripAdvisor's website icon next to the address. Sage Biscuit Cafe offers an extensive menu of creative breakfast and lunch offerings. ![]() There’s just that gratefulness that continuously makes us want to communicate and talk to and interact with our fans more during our shows. Jiung: The reason why we’re able to perform and why we’re on stage is because there are fans that are waiting for us and supporting us. During the show, you interact a lot with the crowd and are super talkative, how does showing love and appreciation to P1ece help engage your performances? I feel like our fans really find it fun to see and we enjoy doing solo and unit stages. These individual characteristics come together and create P1Harmony. ![]() When we take time to do these unit and solo stages, it’s more about who Keeho is, who Intak Is, who Jongseob is, who Theo is, who Jiung is, who Soul is, and showing off who we are individually. When we just do P1Harmony stages, our biggest goal is to show P1Harmony. It’s a really fun part of our show because we get to show what we like and what we can do. We put a lot of effort into our unit and solo stages because those are the only times where we get to show our individual colors, talents and strengths. Keeho: We take a lot of pride and do so much practice. What does it feel like to shine in your own talent and have the members support you in that sense? In a portion of the concert, you split off for your solo and unit stages and each one of them is beyond incredible. Shortly after, Intak and Jongseob swept the stage with their cool and ferocious raps and dances in their unit stage. ![]() Keeho stunned the entire venue with his impressive vocal runs when covering “Deja Vu” by Beyoncé and the latter two boys joined Jiung in an explosive cover of “Love Never Felt So Good” by Michael Jackson. Theo kicked it off with his cover of “21” by Dean by sitting slickly on a staircase and Soul switched gears up when he sang the emotive “Hug Me” by Jung Joon-Il. The members performed non-stop throughout the first portion of the show with hits from their latest EP HARMONY: SET IN like “Look At Me Now” and “Back Down.” They seamlessly transitioned from being a cohesive team with the impassioned and forceful “Black Hole” (a favorite of Keeho, Theo and Intak) to splitting up in their respective solo and unit stages. Though they debuted in the midst of the COVID pandemic in 2020 with FNC Entertainment, they’ve become veterans in performing across the globe and they’re doing it with ease, too.Īt their show at Terminal 5 in New York City, the venue was booming with adoring love for the members. leg of their second world tour P1ustage H: P1ONEER on January 20, 2023. The six-piece K-Pop group consisting of Keeho, Theo, Jiung, Intak, Soul and Jongseob, embarked on the U.S. P1Harmony definitely has the secret sauce. ![]() Why does a tropical-looking island sound like a place you’d find off the coast of Massachusetts? Don’t worry, we’ll address that later.īaker has a lot on his mind. That’s the name of McConaughey’s character in Serenity, a fisherman with a mysterious past living on Plymouth Island. Matthew McConaughey and the Moby Dick of Tunaīaker Dill. This is the five-step process of experiencing an instant so-bad-it’s-good classic. Serenity is an early and clear front-runner for WTF movie of the year.įair warning: From this point forward, everything about Serenity is going to be spoiled, in the order of the film’s bizarre narrative developments-which, conveniently, double as a rising scale of WTF moments leading all the way to the film’s conclusion. If you had told me the plot machinations of Serenity outright, I’d have politely asked to check your kitchen cabinets to ensure nothing was somehow laced with LSD. You could’ve offered me a thousand opportunities to guess what the movie’s really about, and I’d never have solved it. Nothing could’ve prepared me for Serenity-its ridiculous dialogue, fish-obsessed characters, and all-time bonkers plot twist. Well, having finally seen Serenity, let me just say: REOPEN ALCATRAZ AND GIVE STEVEN KNIGHT A LIFETIME SENTENCE. I didn’t want to know the details, but obviously, there was more to Serenity than meets the eye. Sexy fishing noir actually seemed to track, and seemed like a fun enough time.īut then, a week before the release, Polygon reporter Karen Han described it to me as “deranged.” “Arrest Steven Knight,” she added. If you watched only the trailer, you’d think you understand the basic premise: Matthew McConaughey is a fisherman on some tropical island who is approached by his ex-wife, Karen (played by Anne Hathaway), who’s willing to offer him $10 million if he will take her abusive, wealthy husband, Frank (Jason Clarke), out on his boat and dump him to feed the sharks. You don’t really need to read the tea leaves here: Serenity, a movie genuinely described by writer-director Steven Knight as a “sexy fishing noir,” was originally scheduled to come out in October and finally arrived in theaters this weekend. The hope is that enough people will emerge from their post-holiday idleness and spend their money on a (probably terrible) movie and, with any luck, that studio can turn a marginal profit. January is typically the ceremonial dumping ground for films that studios wish to forget about. ![]() It’s rarely a good sign when a movie slated for release in October, a month annually populated by Best Picture contenders ( A Star Is Born) and box office phenomenons ( Venom), gets pushed all the way to January. |
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